Meldonium Injections



How to take the medicine Mildronate injections?

Always take this medicine exactly as your doctor has told you. If you are unsure, ask your doctor or pharmacist.

Mildronate is given intravenously (into a vein). The medicine does not require any special preparation before administration.

Because of the possible stimulant effect, it is recommended to take it in the first half of the day.



The dose is 500 mg-1000 mg (5-10 ml) intravenously, administered immediately or divided into two administrations. The duration of treatment is usually 10-14 days, followed by continued treatment with the oral form.

The duration of the treatment course is 4-6 weeks. The course of treatment can be repeated 2-3 times a year.

Other medicines and Meldonium injections

Tell your doctor or pharmacist about all the medicines you are taking, have taken recently or could
– Mildronate may be used together with extended-release nitrates and other antianginal agents
for the treatment of stable angina pectoris, cardiac glycosides and diuretics (promote
urine production and excretion) for the treatment of heart failure.
– Meldonium injections may be combined with anticoagulants (inhibit blood clotting), antiaggregants (prevent blood clots in the blood vessels), medicines to prevent heart rhythm problems and other medicines, which improve microcirculation (blood flow in small blood vessels).
– Mildronate injections may strengthen the effects of glyceryl trinitrate-containing medicines, nifedipine, beta-blockers, other blood pressure-lowering drugs and blood vessel dilators.
– In patients with chronic heart failure, for symptom relief, concomitant treatment with meldonium may be prescribe lisinopril.
– Additional effects have been observed with meldonium in combination with orotic acid for ischaemia/blood flow to prevent damage caused by restoration of blood flow.
– Concomitant use of ferrous sulphate and meldonium in patients with iron deficiency
anaemia, the fatty acid composition of red blood cells is improved.
– Meldonium injection overdose may potentiate the toxic effects of cyclophosphamide on the heart.
– Carnitine deficiency resulting from D-carnitine (an inactive isomer of carnitine)-meldonium
may potentiate cardiac toxic effects due to ifosfamide.
– Meldonium shows protective effects against indinavir-induced cardiac toxicity and
efavirenz-induced neurotoxicity.


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